Seminal Publications

Seminal Publications

1983 “Characteristics of the acquired immunodeficiency syndrome (AIDS) in Haiti.” The first description of the syndrome in a tropical developing country. The New England Journal of Medicine309:945-50.
1985 “The acquired immunodeficiency syndrome in Haiti.” Identified the role of contaminated blood transfusions early in the HIV epidemic in Haiti. Annals of Internal Medicine 103:674-8.
1986 “Clinical manifestations and therapy of Isospora belli infection in patients with the acquired immunodeficiency syndrome.” Described isosporiasis in AIDS patients and the effectiveness of trimethoprim-sulfamethoxazole in therapy and prevention of recurrence. The New England Journal of Medicine 315:87-90.
1989 “Treatment and prophylaxis of Isospora belli infection in patients with the acquired immunodeficiency syndrome.” Established the efficacy of trimethroprim-sulfamethoxazole in initial therapy and prophylaxis of cyclosporiasis and isosporiasis. The New England Journal of Medicine 320:1044-7.
1993 “Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection.” Determined that isoniazid prevents tuberculosis and delays the progression of HIV infection to disease in symptomatic HIV persons. The Lancet 342:268-72.
1996 “Heterosexual transmission of HIV in Haiti.” Described the dramatic shift in HIV transmission in Haiti from blood transfusions and men who have sex with men to the general population. Annals of Internal Medicine 125:324-30.
2000 “Effect of post-treatment isoniazid on prevention of recurrent tuberculosis in HIV-1-infected individuals: a randomized trial.” Documented the high rate of tuberculosis recurrence after therapy in patients with AIDS and the value of post-treatment secondary prophylaxis. The Lancet 356:1470-4.
2000 “Trimethoprim–sulfamethoxazole compared with ciprofloxacin for treatment and prophylaxis of Isospora belli and Cyclospora cayetanensis infection in HIV-infected patients.” Established ciproflaxin as acceptable therapy for patients with cyclosporiasis and isosporiasis who cannot tolerate trimethoprim-sulfamethoxazoleAnnals of Internal Medicine 132:885-8.
2002 “Comprehension during informed consent in a less-developed country.” Evaluated comprehension during the informed consent process and made recommendations for improvement in developing country settings. The Lancet 360:1301-2.
 
2003 “Decreased congenital syphilis incidence in Haiti’s rural Artibonite Region following decentralized prenatal screening.” Described improved program for syphilis screening and treatment for pregnant women to prevent congenital syphilis. The American Journal of Public Health 93:444-6.
2005 “Antiretroviral therapy in a thousand patients with AIDS in Haiti.” Reported GHESKIO’s experience treating the first 1,000 AIDS patients with outcomes comparable to US clinics. The New England Journal of Medicine 353:2325-34.
2007 “Antiretroviral therapy for HIV-1-infected children in Haiti.” Reported efficacy and feasibility of delivering pediatric antiretroviral therapy in Haiti. The Journal of Infectious Diseases 195:1396-8.